Understanding the biological complexities within the modular organization of cells.

KEY FOCUS:

  • Systems based approaches to reveal and understand complex biological phenomena focusing on yeast as a model for developing systems biology approaches to infectious disease research. Understanding cellular function from this perspective is essential to developing strategies for intervention when these functions go awry, causing diseases (such as neuropathologies or cancer) or are usurped in the cases of infection by pathogens.
  • The molecular mechanisms responsible for the biogenesis of peroxisomes – an organelle in the cytoplasm of cells that is responsible for numerous metabolic and signaling functions. Defects in peroxisomal functions have been associated with neuropathologies, diabetes, obesity, metabolic syndrome, cancer and aging.
  • The development of innovative and dramatically new approaches for the detection, isolation, and analysis of macromolecular complexes that will enable scientists to realize the full potential of the revolution brought about by genomics, interdisciplinary research, and proteomics technologies.